Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative stress is one of the main pathogenic pathways in IPF.
REVIEW Open Access Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review Alessandro G. Fois1,2*†, Panagiotis Paliogiannis3†, Salvatore Sotgia3, Arduino A. Mangoni4, Elisabetta Zinellu2, Pietro Pirina1,2, Ciriaco Carru3 and Angelo Zinellu3 Abstract
Evaluation and therapeutic applications of oxidative stress biomarkers in idiopathic pulmonary fibrosis: a systematic review.
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Here we review the role of oxidative stress in IPF, and other forms of pulmonary fibrosis, with particular attention to antioxidant defenses regulated by the redox-sensitive transcription factor nuclear factor, erythroid derived 2, like (Nrf2).
Abstract: Idiopathic pulmonary fibrosis (IPF) is a serious and deadly disease for which treatment options are limited. The recent approval of antifibrosis agent nintedanib represents one of the first therapeutic approaches for the treatment of IPF.
ROS and oxidative stress have been implicated in a number of diseases, including fibrosis and cancer . NOX-derived ROS have been identified as the main source of oxidative stress, which promotes key events in the development of fibrotic diseases (such as skin fibrosis  , idiopathic pulmonary fibrosis  , liver fibrosis  , and kidney fibrosis  ) as well as the initiation and progression of cancer  .
Background. Oxidative stress (OS) and reduced nitric oxide (NO) bioavailability contribute to the pathogenesis of pulmonary hypertension (PH). Whether there are associations between OS and NO signaling biomarkers and whether these biomarkers are associated with the …
Recent studies have therefore focused on noninvasive techniques to evaluate oxidative stress, e.g., in inflammatory lung diseases such as asthma, COPD, and cystic fibrosis. The assessment of biomarkers of oxidative stress in exhaled breath condensate is one such approach and is emerging as a promising area of future research in inflammatory lung diseases .
Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review Alessandro G. Fois , Panagiotis Paliogiannis , Salvatore Sotgia , Arduino A. Mangoni , Elisabetta Zinellu , Pietro Pirina , Ciriaco Carru , Angelo Zinellu
Exhaled breath condensate (EBC) collection is a noninvasive method to investigate pulmonary oxidative stress biomarkers such as malondialdehyde (MDA). Subjects and Methods. We measured MDA levels in EBC in a large number of patients () with respiratory diseases: asthma (), bronchiectasis (BE, ), chronic obstructive pulmonary disease (COPD, ), idiopathic pulmonary fibrosis (IPF, ).
MMP-9 plays an important role in human and experimental lung fibrosis and it is elevated in patients with idiopathic diseases (Pardo and Selman, 2006). This current data has shown that MMP-9 was a target of the vitamin D actions, as the MMP-9 releases were impaired by the treatments.
Nowadays, phytotherapy has gained a considerable attention in the treatment of PF both in vivo and in vitro using bleomycin (BLM)-induced lung inflammation, oxidative stress and pulmonary fibrosis in rats. In this review, we aimed to focus on the protective effects and the mechanisms of action of several plant extracts described by various research works for the treatment of PF.
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative stress is one of the main pathogenic pathways in IPF.