title = «Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema», abstract = «Smoking is a common risk factor for both chronic obstructive pulmonary disease (COPD) and osteoporosis.
Several pulmonary emphysema models exist , such as smoking exposure models, transgenic animals, and elastase-induced emphysema models. The smoking exposure model is the one most commonly used as a COPD animal model, and it demonstrates the deterioration of bone quality . However, there is no unified experimental protocol . In addition, the degree of emphysema is mild; therefore, it may be the …
There is still much to learn about the specific mechanisms by which cigarette smoke residues (THS) harm nonsmokers but that there is such an effect is now clear. Our studies in mice that are never exposed to smoke itself but are exposed to residues of the smoke, strongly implicate tobacco smoke residues in these pathologies.
Published in: PLOS ONE · 2014Authors: Manuela Martinsgreen · Neema Adhami · Michael Frankos · Mathew Valdez · Benjami…Affiliation: University of California Riverside · University of California San Francisco · San Diego …About: Toxicology · Wound healing · Biology · Fatty liver · Global health · Neuroscience
Tamaki J et al (2010) Impact of smoking on bone mineral density and bone metabolism in elderly men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study. Osteoporos Int Google Scholar 19.
Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema. Mamoru Sasaki, Shotaro Chubachi, Naofumi Kameyama, Deteriorating Effect on Bone Metabolism and Microstructure by Passive Cigarette Smoking Through Dual Actions on Osteoblast and Osteoclast.
Jul 09, 2013 · Long term positive effects can be seen on the bone metabolism, as shown by the increase of BMC at different sites, and by the reduced incidence of fractures49. More evident results can be obtained from smoking cessation in the short term, in patients submitted to orthopaedic surgery, being the healing process improved, the frequency of complications reduced, and the length of hospital stay …
Chronic cigarette smoke (CS) exposure provokes variable changes in the lungs, and emphysema is an important feature of chronic obstructive pulmonary disease. The usefulness of micro-computed tomography (CT) to assess emphysema in different mouse models has been investigated, but few studies evaluated the dynamic structural changes in a CS-induced emphysema mouse model.
Cigarette smoking increases a person’s metabolic rate slightly by forcing the heart to beat faster. When a cigarette is inhaled, a smoker’s heart can beat 10 to 20 times more per minute for a period of time. This causes extra stress on the heart and plays a role in heart disease, the most common cause of …
The effect of long-term exposure to cigarette smoke on the height and specificity of the secondary humoral immune response to influenza was investigated in a murine model system.
Tolerance – need larger dose – 2/4 cigarettes initially but need 20/40 cigarettes after long term smoking Withdrawal Substance taken in larger amounts or longer than intended A higher priority given to drug use than to other activities and obligations A great deal of time is spent in obtaining, using or recovering from effects of substance
effects.5-7 The rates of exposure to secondhand smoke have lead it to be the third leading cause of preventable death in America. The musculoskeletal system- the bones, muscles, tendons, ligaments and nerves in the body- is significantly affected by tobacco exposure. Tobacco smokers experience a decrease in bone mineral
Therefore, fetal and neonatal exposure to nicotine, via NRT or cigarette smoking, may similarly increase the long-term risk of developing cancer, although more research is …
However, this study did not include the effect of water insoluble components of cigarette smoke and the effect of CSE on long term exposure beyond the 72 hrs. Therefore, any future study should include the effect of long-term exposure of water soluble as well as insoluble components on conformation integrity and biological activity of proteins.
Tobacco use has predominantly negative effects on human health and concern about health effects of tobacco has a long history. Research has focused primarily on cigarette tobacco smoking. Tobacco smoke contains more than fifty chemicals that cause cancer. Tobacco also contains nicotine, which is a highly addictive psychoactive drug.